trazodone hydrochloride
CLINICAL USE
Antidepressant
DOSE IN NORMAL RENAL FUNCTION
Depression: 100–300 mg daily; maximum 600 mg daily in divided doses for hospital patients Anxiety: 75–300 mg daily
PHARMACOKINETICS
Molecular weight : 408.3 %Protein binding : 89–95 %Excreted unchanged in urine : <5 Volume of distribution (L/kg) : 1–2 half-life – normal/ESRD (hrs) : 5–13/ – DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50 : Dose as in normal renal function 10 to 20 : Dose as in normal renal function. Start with small doses and increase gradually <10 : Start with small doses and increase gradually DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD : Unlikely to be dialysed. Dose as in GFR <10 mL/min HD : Unlikely to be dialysed. Dose as in GFR <10 mL/min HDF/high flux : Unknown dialysability. Dose as in GFR <10 mL/min CAV/VVHD : Unknown dialysability. Dose as in GFR 10 to 20 mL/min IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs Alcohol: increased sedative effects Antidepressants: avoid concomitant use with MAOIs and moclobemide Anti-epileptics: antagonism of anticonvulsant effect Antimalarials: manufacturer advises avoid concomitant use with artemether and lumefantrine Sibutramine: increased risk of CNS toxicity – avoid concomitant use ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
– Comments
– OTHER INFORMATION
Use lower doses in elderly patients The majority of a dose (75%) is excreted by the kidney, mainly as metabolites
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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